Yes, I played RoF; Lockon 2.0; DCS Blackshark; DCS A10c beta; Tropico 3; Cities XL 2011; Silent Hunter V; and a few others on full settings with great FPS and no problems.
A few weeks ago while this was crashing Jedi suggested that I try and fly a stock IL2 4.09 with no mods and set the graphics settings in IL2set to 'Safe Settings'. That sounded like a good test, and I did have a stock unmodded game folder handy. It worked great... for about 30 minutes, then it also crashed same as usual. Really weird...